After recording two outs to start the frame, the Rockies blew the game even more wide open as Spilborghs and Helton each singled. With Tulo up, Caridad picked Helton off of first base but his throw was wild and went down the right field line scoring Spilborghs and getting Helton to third. Helton scored when Tulo hit a double to center field to make it an 8-0 Rockies lead. Brad Hawpe, like in the first and second innings, ended the inning (this time, it was on a flyball, though). However, Tulo was already three-quarters of the way to the cycle in the fourth inning.
In the fifth inning, with the exception of a walk to Derrek Lee, each team went down quickly (on a combined 25 pitches).
In the top of the sixth inning, Geovany Soto lead off the inning with a solo homer off De La Rosa to make it an 8-1 Rockies lead.
With the exception of a double by De La Rosa to lead off the bottom of the sixth inning, nothing happened for either team in the bottom of the sixth or top of the seventh inning. However, the Rockies and 34,485 in attendance, plus countless more listening on radio or watching on television were looking forward to the bottom of the seventh inning as Tulo would be leading off the inning…looking to make history.