In the top of the second inning, Jorge De La Rosa gave up a single to Sam Fuld and a walk to Theriot but, like the first inning, he got out of it unscathed.
In the bottom half of the second inning, the Rockies roughed Gorzelanny up as he allowed a home run to Clint Barmes with one out. Five pitches later, he gave a double up to Yorvit Torrealba. Two pitches later, De La Rosa helped his own cause as he got a single that advanced Torrealba to third base.
Fowler scored Torrealba with a swinging bunt single to the pitcher’s mound to make it a 4-0 game. Cubs manager Lou Piniella had seen enough from Gorzelanny and replaced him with reliever Esmailin Caridad. Two batters later after Fowler, Helton walked and the eventual player of the day, Troy Tulowitzki, got a single to score De La Rosa and Fowler to make it a 6-0 Rockies lead. Like the first inning, Brad Hawpe ended the inning by striking out but Troy Tulowitzki was already half way to the cycle.
In the third inning and in the top of the fourth inning, De La Rosa and Caridad faced the minimum (Caridad hit Barmes but he was retired two pitches later when Torrealba grounded into a double play).